The Herceptin, Cyclophosphamide, and Epirubicin (HERCULES) trial evaluated trastuzumab plus cyclophosphamide and the less cardiotoxic anthracycline epirubicin. Contents; Search; Corneal Endothelial Rejection Line. First Online: 06 . Jul 2011 - Present10 years 10 months. 1,3 It occurs in 25% of the United States population and is associated with atopic disease, including rhinitis, asthma and eczema. Purpose: To describe the presence of an endothelial rejection line in immunological graft rejection after Descemet stripping automated endothelial keratoplasty (DSAEK). provide evidence for the abundant presentation of MHC class II restricted neoantigens in human B cell lymphomas. • Ferry's Line = corneal epithelial iron line at the edge of filtering blebs. Allergic conjunctivitis.This typically presents with symptoms of itching and eye rubbing. Global. Khodadoust Line. mkhodado@stanford.edu m. s. khodadoust, n. ganesan, e. drill, h. hancock, t. davey, p. myskowski, c. maccaro, w. blouin, j. schwieterman, e. cathcart, s. fang . Dr. Michael S Khodadoust is licensed to practice by the state board in California (A118295). 56-year-old female status post full-thickness corneal transplant presented to our clinic with signs of endothelial cell rejection. Corneal Transplant - 15 images - corneal transplant denver cornea fort collins, corneal transplantation grafting corneal keratoplasty, cornea transplant, corneal transplant london fuch s dystrophy lexington ky, An understanding of the resistance mechanisms will shed light on the disease biology and inform selection of next line therapies and the development of future CCR4-directed treatments for patients with cutaneous T cell lymphoma (CTCL). This "rejection line" usually begins in one area of the cornea and marches across the endothelium over . In a retrospective analysis of 65 patients, with a median follow-up of 48 months, use of ECP in the first to third line of treatment yielded a longer median time-to-needing-treatment than . Complete healing of the donor-host corneal complex can take up to 24 months; however, the average time frame to begin considering contact lens fitting varies from six to 12 months after surgery. Ibrutinib is . Kaposi Sarcoma (KS) is an angioproliferative neoplasm driven by human herpes virus 8 (HHV-8), classically described in HIV populations, although also occurring in HIV-negative patients (classic, endemic, and iatrogenic). • Hudson-Stahil Line= Horizonatl corneal epithelial iron line at the inferior one third of cornea due to aging. While metformin remains first-line for the treatment of type 2 diabetes, 2 new classes of medications (sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide agonists) are becoming mainstays in therapy. The presentation of endothelial rejection in DSAEK is atypical in that a Khodadoust line is rarely seen [127, 128]. Ophthalmology 2003; 110:1601-1605. Behrouzi Z, Khodadoust A. Epithelial iris cyst treatment with intracyst ethanol irrigation. One of the characteristic signs of graft rejection is the Khodadoust line (black arrow), which is the accumulation of inflammatory cells at the corneal endothelium. In 2016, approximately 83,000 corneal transplantations were performed in the United States. Due to the absence of donor epithelium and stroma, and lack of direct contact of . MIT Medical's Student Mental Health and Counseling Services works with students to identify, understand, and solve problems, and to help transform that understanding into positive action. It was established to provide hospital services for those seeking eye treatments. In the area of damage, the endothelium is decompensated resulting in stromal and epithelial edema. However, it can take several months before the eye settles down. A Khodadoust line or chronic focal transplant reaction is a medical sign that indicates a complication of corneal graft surgery on the eye. To report a case of herpes simplex virus (HSV) linear endotheliitis in a 57-year-old male who had underwent keratoplasty 10 years ago. The front-line treatment algorithm for patients with CLL is illustrated in Figure 1. Results: A 77-year-old woman underwent DSAEK procedure of the left eye because of visual limiting bullous keratopathy. Purpose A high incidence of congestive heart failure (CHF) has been observed in patients with metastatic breast cancer (MBC) receiving doxorubicin-based chemotherapy and trastuzumab. Immunohistochemistry (IHC) and gene sequencing are the main analysis methods for the TME but are limited due to the subjectivity of observers, the high cost of equipment and the need for professional analysts. . . The purpose of this study is to evaluate the efficacy, safety and tolerability of the combination treatment of ibrutinib and MEDI4736 in subjects with relapsed or refractory lymphomas. 2]. Ali Asghar Khodadoust, MD, internationally recognized corneal transplant surgeon, died on March 9, 2018 at the age of 82. . Treatment of graft rejection depends on the type of rejection; however, in all cases, topical corticosteroids are the mainstay of treatment. This may be the first report of graft . Corneal endotheliitis is a corneal endothelium-specific inflammation first described by Khodadoust and Attarzadeh in 1982.1 It is characterised by corneal oedema, keratic precipitates (KPs), a mild anterior chamber reaction, and the destruction of corneal endothelium. Division of Oncology, Department of Medicine, Stanford . Background: Over the past decade endothelial keratoplasty has become the treatment of choice for patients with corneal endothelial dysfunction. Reference work entry. : Pembrolizumab in Relapsed and Refractory Mycosis Fungoides and Sézary Syndrome: A Multicenter Phase II Study. 1 Allergic conjunctivitis can be season-specific or perennial, which continues throughout the year. . Search SpringerLink. . Patients and Methods This prospective trial combined . One week postoperatively, the donor lamella was partially detached and an additional . Khodadoust Line. He was honored by UNESCO in 2015. Michael Khodadoust et al. He is affiliated with numerous hospitals in California and more, including Stanford Health Care. Review of 40 histologically proven cases of epithelial downgrowth following cataract extraction and suggested surgical management. Self-Employed. The landscape of diabetes treatment has evolved significantly in recent years. Contact. Michael Khodadoust is on CAP Network. Degree of doctorate in medicine from Shiraz University of Medical Sciences (1954-1960) Resident in ophthalmology & ENT (1960 -1961) Purpose Outcomes for patients with diffuse large B-cell lymphoma remain heterogeneous, with existing methods failing to consistently predict treatment failure. Visit Stanford Children's Health's online second opinion page for more information. Slit-lamp photo showing (A) endothelial graft rejection with a Khodadoust line and keratic precipitates in a penetrating keratoplasty graft, (B) deep anterior lamellar keratoplasty graft . This method is called Khodadoust Line because of many years research about this by Professor Ali Asghar Khodadoust. There was an advancing horizontal Khodadoust's rejection line in the center of the endothelium with graft edema at its wake inferiorly [Fig. The rejected graft cornea also shows corneal edema in the involved area. The patient was diagnosed with acute corneal graft rejection and advised hourly topical steroids with cycloplegics and oral steroids. (650) 498-6000 (office) Clinical Stanford Cancer Center 875 Blake Wilbur Dr Rm CC2325 MC 6505 Stanford, CA 94305. Thank you for your interest in the program. Part time to full time starting in 2013. A posterior khodadoust line in a graft rejection episode after descemet stripping automated endothelial keratoplasty. Although described for more than 100 years, corneal transplantation has become increasingly common since the 1960s. This specialized eye hospital continues to work with the help of the most experienced and committed . Additionally, monochemotherapy has changed from being a second-line treatment to a first-line treatment for Stage IIB MF. The tumor microenvironment (TME) plays an important role in the occurrence and development of gastric cancer (GC) and is widely used to assess the treatment outcomes of GC patients. KHODADOUST LINE A Khodadoust Line or chronic focal transplant reaction is a medical sign that indicates a complication of corneal graft surgery on the eye. Find Dr. Sokol's phone number, address, insurance information, hospital affiliations and more. . Patients and Methods We studied the dynamics of ctDNA from 217 patients treated at six centers . oped an endothelial rejection line [2]. Delving further into data science/coding, and interested in epigenetic research studies . In a case series of 4 eyes, the type of KPs and CMV viral load were studied throughout treatment. Using the Raji lymphoma cell line, we tested whether . Because the treatments for HSV linear endotheliitis and the corneal graft rejection line are totally different, differential diagnosis is essential. efficacy and safety of ibrutinib . The graft superior to the rejection line was clear [Fig. This line resembles a rejection line (Khodadoust line), which is a characteristic finding of graft rejection in keratoplasty. So far, in this column series . Inclusion Criteria. Maumenee AE, Paton D, Morse PH, et al. . . Patients with early-stage and locally advanced NSCLC usually receive curative-intent first-line treatment such as tumor resection, radiotherapy, and/or combined approaches such as radiochemotherapy and adjuvant systemic treatment including chemotherapy or immune checkpoint blockade [[3-5]]. Flickr photos, groups, and tags related to the "khodadousteyehospital" Flickr tag. These … This article reviews these options, what patients need to know and the . Slit-lamp examination showed donor stromal edema with Descemet's membrane folds and Khodadoust line (KP's on endothelium) with anterior chamber cells and flare. 3. Lines & Rings in Ophth. In this analysis, over a median follow-up of 207 and 176 weeks in the bevacizumab and control treatment groups, respectively, we observed an endothelial rejection rate of 3% in the bevacizumab treatment group versus 38% in the control treatment group (p=0.003) and an overall graft failure rate of 61% in the bevacizumab treatment group and 66% . Molecular testing for 17p deletion and IGHV mutation status (or flow-cytometric determination of ZAP-70, CD38, and CD49d expression if determination of IGHV mutation status is unavailable) is highly recommended if chemo-immunotherapy is considered. Treatment for limited cutaneous lesions consists of skin-directed local therapy, such as intralesional chemotherapy, radiation therapy, and topical agents. Hepatitis C (hep C) is a liver infection caused by the hepatitis C virus (HCV). Immediate immunosuppression treatment is necessary to prevent further damage because, without treatment, the line of WBC will move across and damage the endothelial cells within several days. Exercise. Clinical Medicine 300 Pasteur Dr Rm JC007 Stanford CA 94305 Tel: (650) 725-5071 Fax: (650) 725-8381. Ferry's Lines in Eyes Has an active autoimmune disease that has required systemic treatment in the past 2 years (i.e., with use of disease modifying agents, corticosteroids, or immunosuppressive drugs); replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or . Khodadoust MS, Rook AH, Porcu P, et al. captivate primary analysis of first-line treatment with fixed-duration ibrutinib plus venetoclax for chronic lymphocytic leukemia (cll)/small lymphocytic lymphoma (sll) . A Khodadoust line is made up of white blood cells (mononuclear cells) at the vascularized edge of the recently transplanted cornea. This shows the importance of early recognition and prompt treatment for a . Dr. Michael S Khodadoust also practices at 1804 Embarcadero Road, Palo Alto, CA. The diagnosis of immunologic graft failure is made if signs of rejection do not clear within 2 months of treatment. CAP Network is a virtual workspace, to support collaboration among faculty, graduate students, postdocs and staff. 20, . Stanford is currently not accepting patients for this trial. Lung cancer is the leading cause of cancer and cancer-related mortality worldwide ().In patients with nonmetastatic lung cancers, a subset can be cured after primary surgical resection, radiotherapy, and/or combined treatment approaches, including chemotherapy ().Following curative-intent first-line therapies, current routine clinical surveillance involves serial radiographic imaging (). Khodadoust et al. The classic endothelial rejection line should be kept in mind as a rare sign of DSAEK graft rejection. Frequently Asked Questions. Log in; Encyclopedia of Ophthalmology. Cycloplegics. Introduction. A Khodadoust line separates immunologically damaged endothelium from unaffected endothelium. 1 a, b). Khodadoust MS, Rook AH, Porcu P, et al. We examined the additional prognostic value of circulating tumor DNA (ctDNA) before and during therapy for predicting patient outcomes. Treatment for corneal allograft rejection was started. In line with findings in other fields of medicine, data suggest that pulsed intravenous (IV) steroids may be more effective than oral prednisone in reversing corneal graft rejection. In a retrospective analysis of 65 patients, with a median follow-up of 48 months, use of ECP in the first to third line of treatment yielded a longer median time-to-needing-treatment than . Here is an example of severe linear endotheliitis. . Stage IV intrahepatic cholangiocarcinoma (ICC) patients have very poor survival outcomes. : Pembrolizumab in Relapsed and Refractory Mycosis Fungoides and Sézary Syndrome: A Multicenter Phase II Study. حقن الشبكية لمرضى السكري في مستشفى خدادوست للعيون توفر مستشفى خدادوست للعيون في مدينة شيراز حقن العين لعلاج الشبكية والتي تعتبر إجراء غير مؤلم على. Khodadoust: Alexion . The authors recommended that combined topical steroid with antiviral therapy might be indicated in CMV endotheliitis with sectoral corneal edema with and without Khodadoust line-like KPs and mutton-fat KPs. 4. Search. If you were . The patient responded to treatment and there was progressive reversal of graft . The corneal edema extended from the limbus to the Khodadoust line-like KPs at 2 and 11 o'clock (Fig. Mantle cell lymphoma (MCL) is an incurable non-Hodgkin lymphoma that carries a poor prognosis regardless of therapy. Symptoms include redness of . This method is called Khodadoust line because of many years research about this by Professor Ali Asghar Khodadoust.This medical condition is similar to organ rejection after an organ transplant, except that it involves immunological rejection of a . Eat balanced. Median duration of treatment with moga was 3.5 months (range: 2-41). 1 The seasons most often associated with allergic conjunctivitis are spring . [ 1] Corneal graft rejection is the most common cause of graft failure in the late postoperative period. M S Khodadoust, B Luo, B C Medeiros, J L Zehnder & J Gotlib Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA B Luo, R C Johnson, M D Ewalt, C D Bangs, A M Cherry . This medical condition is similar to organ rejection after an organ . The characteristic linear keratic precipitates (KPs) resembled the Khodadoust line in graft rejection. (HSV vs. cytomegalovirus), with an exception for Khodadoust's line, which can be seen in endothelial graft rejection. Although optical rehabilitation with contact lenses can start as early as three months after transplantation, the clinical status of the grafts and . Purpose: To describe the presence of an endothelial rejection line in immunological graft rejection after Descemet stripping automated endothelial keratoplasty (DSAEK). Stanford School of Medicine . . On the posterior surface of the cornea, there was an endothelial rejection line (Khodadoust line) with keratic precipitates and multiple areas of anterior synechia. Avoid alcohol. (2020) 49: Pegylated liposomal doxorubicin: Chemotherapy: Pegylation of doxorubicin in liposomal form leads to a longer half-life with reduced toxicity: . 1,3 It occurs in 25% of the United States population and is associated with atopic disease, including rhinitis, asthma and eczema. 10 A Khodadoust line consists of segmented corneal edema and endothelial white blood cells adjacent to an area of clear cornea . Gemcitabine plus cisplatin chemotherapy is currently recommended as the only first-line treatment for these patients, with a median overall survival (OS) of only 11.7 months ().The worst is that more than 70% of patients are intolerable to the chemotherapy regimen because of severe . For any questions or concerns please reach out to +1- 650-724-1200 or DL-CAS-Second-Opinion@stanfordhealthcare.org. • Khodadoust Line = corneal graft endothelial . 2. Takeaway. KHODADOUST LINE A Khodadoust Line or chronic focal transplant reaction is a medical sign that indicates a complication of corneal graft surgery on the eye. There are reportedly four clinical forms of cornea endotheliitis, of which, linear corneal endotheliitis is . Intracameral/ intravitreal triamcinolone (resistant cases) Khodadoust line, sharply demarcated line of KPs Diffuse KPs (69%) Stromal and epithelial edema (11%) Conjunctival hyperemia; AC reaction: flare, cells; Topical steroids + Subconjunctival steroid/ oral prednisone/ i.v. Student Mental Health and Counseling Services is available for telehealth visits* and in-person appointments. Manage mindset. . Introduction. We are currently not accepting new case requests. Chronic Focal Transplant Reaction, Khodadoust Line: Corneal Abscess After Immunereaction: Graft failure after Perforating Keratoplasty with Athalamia: Hyperacute Stromal Transplant Reaction: Vascularized Scar of Corneal Transplant: Allergic conjunctivitis.This typically presents with symptoms of itching and eye rubbing. The endothelial rejection line (Khodadoust line) is an aggregation of lymphoid cells on the corneal endothelial side and is a sign of immunologic cor-neal allogenic graft rejection [10], which has been classically described after PKP. lmaeda@stanford.edu. Assistant Professor of Medicine, Depts of Medicine (Oncology) & Dermatology . Maintain moderate weight. traZeneca). Risk Factors For more information, please contact Cancer Clinical Trials Office (CCTO), 650-498-7061. Dr. Lubomir Sokol is a Hematologist in Tampa, FL. The most common form of rejection in up to 50% of cases is endothelial rejection, which is associated with limbal engorgement, corneal graft edema, anterior chamber reaction, keratic precipitates, and a Khodadoust line. We see nearly 21 percent of the student body each year, and about 29 percent of students in a . • Arlt's Line = conjunctival scar in sulcus subtarsalis in Trachoma. This method is called Khodadoust Line because of many years research about this by Professor Ali Asghar Khodadoust. Skip to main content Skip to table of contents. 1 The seasons most often associated with allergic conjunctivitis are spring . Shiraz University of Medical Sciences (SUMS) (Persian: دانشگاه علوم پزشکی شیراز Dāneshgāh-e Olum Pezeshki-e Shirāz) is a public medical school located in Shiraz, Iran.It is ranked as one of Iran's top medical schools, with more than 9000 students studying in over 200 different disciplines, and a faculty staff of nearly 900 and 25,000 personnel. Corneal Transplant - 15 images - corneal transplant denver cornea fort collins, corneal transplantation grafting corneal keratoplasty, cornea transplant, corneal transplant london fuch s dystrophy lexington ky, Methods: "Descemet stripping automated endothelial keratoplasty" (DSAEK) is one of the most widespread forms of posterior endothelial keratoplasty. . حقن الشبكية لمرضى السكري في مستشفى خدادوست للعيون توفر مستشفى خدادوست للعيون في مدينة شيراز حقن العين لعلاج الشبكية والتي تعتبر إجراء غير مؤلم على. Drink water. Am J Ophthalmol 1970; 69:598-603. 1] and grade 2 anterior chamber reaction. Khodadoust AA . Methods: Case report. This family of procedures includes traditional PKP, deep anterior lamellar keratoplasty (DALK), Descemet's stripping endothelial keratoplasty (DSEK/DSAEK), Descemet's membrane endothelial keratoplasty (DMEK) and pre-Descemet's endothelial keratoplasty (PDEK). Background. Degree of doctorate in medicine from Shiraz University of Medical Sciences (1954-1960) Resident in ophthalmology & ENT (1960 -1961) In a study by Jordan et al., no cases of an endothelial rejection line were The differential diagnosis is essential, because the treatment regimen is different between HSV linear . Mogamulizumab is a humanized anti-CCR4 antibody approved for the treatment of mycosis fungoides and Sézary Syndrome. Sara Beygi 1* , George E. Duran 1,2* , Sebastian Fernandez-Pol 3 , Alain H. Rook 4 , Youn H. Kim 1,2 , Michael S. Khodadoust 1,2 Authors’ affiliation: 1. . An improvement of visual acuity is achieved more quickly after DSAEK and the reduced amount of . Michael Khodadoust Assistant Professor of Medicine (Oncology) and of Dermatology Medicine - Oncology CLINICAL OFFICES • Medicine 300 Pasteur Dr Rm JC007 Stanford, CA 94305 Bio Tel (650) 725-5071 Fax (650) 725-8381 CLINICAL FOCUS • Medical Oncology ACADEMIC APPOINTMENTS • Assistant Professor - University Medical Line, Medicine - Oncology HUDSON-STAHLI LINE DrPravinMBhat 37. Dr. KHODADOUST EYE HOSPITAL was officially established, equipped, and launched in Shiraz in 2003, with the help of God, by Professor Ali Asghar Khodadoust. 2018 Edition | Editors: Ursula Schmidt-Erfurth, Thomas Kohnen. Recently, the focus has centered on the intensification of frontline therapy with either higher doses of conventional cytotoxic chemotherapeutics or the addition of cytarabine (Delarue et al., 2013; Geisler et al., 2008; Romaguera et al., 2005). Flickr photos, groups, and tags related to the "khodadousteyehospital" Flickr tag. whether axicabtagene ciloleucel therapy improves the clinical outcome compared with standard of care second-line therapy in patients with relapsed/refractory diffuse large B-cell lymphoma . At least one prior line of chemotherapy; . Saelens IE, Bleyen I, Bartels MC, Van Rij G. Cornea, 30(2):245-246, 01 Feb 2011 Cited by: 2 articles | PMID: 21045664 methyl prednisolone/ dexamethasone ointment at night. In Case 1, various patterns of characteristics, e.g., coin-shaped KPs, sectoral corneal edema with Khodadoust line-like KPs, and mutton-fat KPs over the inferior cornea, were observed before and during the course of treatment. In contrast to other reports, an endothelial rejection line (Khodadoust line) can be seen during the endothelial rejected episode after DSAEK, which is seen in a 77-year-old woman with visual limiting bullous keratopathy. In severe or recurrent cases, this treatment may actually lead to corneal endothelial decompensation and require an endothelial transplant. University - Academic staff Department: Medicine - Med/Oncology Position: Clinical Associate Professor. Diagnosis of either MF or SS by the World Health Organization (WHO) 2016 classification (Swerdlow et al., 2017), stage IB-IV by modified International Society for Cutaneous Lymphomas (ISCL)/ European Organization of Research and Treatment of Cancer (EORTC) classification (Olsen et al., 2011), without large cell transformation (LCT) at the time of screening. of the world's leading corneal graft surgeons and the first to describe the endothelial rejection sign known as the Khodadoust line. This can be seen clinically as a Khodadoust line (arrow), which represents white blood cells on the endothelium. 1 Allergic conjunctivitis can be season-specific or perennial, which continues throughout the year. 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Graduate students, postdocs and staff need to know and the corneal edema and endothelial white cells! Cyst treatment with moga was 3.5 months ( range: 2-41 ) cataract extraction and suggested surgical Management Trials. For more than 100 years, corneal transplantation has become increasingly common since the 1960s Palo Alto, 94305... Diffuse large B-cell lymphoma from 217 patients treated at six centers university - Academic staff Department: -... Mk-3475... < /a > contact Paton D, Morse PH, et al importance of recognition... Schmidt-Erfurth, Thomas Kohnen photos on Flickr | Flickr < /a > Khodadoust line in graft rejection line in graft. The patient was diagnosed with acute corneal graft rejection second-line therapy in patients with relapsed/refractory diffuse large lymphoma! Has evolved significantly in recent years can be season-specific or perennial, which continues throughout the year to hospital. Of many years research about this by Professor Ali Asghar Khodadoust hospital affiliations and more ) is a workspace... Is currently not accepting patients for this trial for any questions or concerns please reach out to +1- or. Season-Specific or perennial, which represents white blood cells adjacent to an area of the left eye because many...
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