eLife transforms research communication to create a future where a diverse . Cell chemical biology. The UW-Madison community was essentially unanimous about three conclusions: the biomedical research enterprise is in urgent need of an overhaul; funding for biomedical research should be increased and stabilized; and robust data and its modeling are woefully lacking but critical for making informed decisions about change. The senior editorial team is comprised of internationally-renowned, active researchers from Europe, North America . . Science, 343 (2014 . Kitaik obtained a bachelor in biotechnology (2004-2011) and the master & PhD in structural biology (X-ray crystallography) from Korea University (2011-2019), working on thiol-oxidoreductases. The rapid and wide adoption of smFRET experiments by an ever-increasing number of groups has generated significant progress in sample preparation, measurement procedures, data analysis, alg … Single-molecule FRET (smFRET) has become a mainstream technique for studying biomolecular structural dynamics. Tiny Crystals Could Revolutionize Structural Biology Studies. Elife. Limit my search to Structural Biology and Molecular Biophysics Research Article; . 7 [DOI] 10.7554/elife.43320. Publisher's Site 2018. This list contains. . Systems Structural Biology Analysis of Ligand Effects on ERα Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Our mission is to accelerate discovery by operating a . Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements . Credit: UCI School of Medicine. Your article has been reviewed by 3 peer reviewers, and the evaluation has been overseen by a Lucie Delemotte as Reviewing Editor and José . Summary. Learn more about what we publish and sign up for the latest research. 7 National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, United States. eLife 9, e61312 (2020). Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. The senior editorial team is today announced for eLife, the new top-tier, open-access research journal to be launched next year with the support of the Howard Hughes Medical Institute, the Max Planck Society and the Wellcome Trust. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware . critically function in triglyceride nucleation and lipid droplet budding from the membrane" for consideration by eLife. . We invited postdocs and independent investigators, who have been running their own group for less than five years, to apply to join our pool of early-career reviewers. He joined our group in July 2019. . "Exploring new ways to evaluate and publish great science is at the heart of what we do at eLife. We visualize the key factors determining different cell morphologies using in situ cellular cryo-electron tomography . Constrained, cyclic peptides encoded by plant genes represent a new generation of drug leads. doi: . Over the past several years, Direct Electron has been . "Biochemically, it is always easier to generate smaller crystals," says structural biologist Tamir Gonen, who developed the . 2017 Jul 6;6:e25835. [A Brilot and N Grigorieff from eLife, 'Structural Biology: . Previously, we reported a low-resolution cryoEM structure of MAVS CARD filament . Structural Biology and Molecular Biophysics; Von Willebrand factor A1 domain stability and affinity for GPIbα are differentially regulated by its O-glycosylated N- and C-linker. The rapid and wide adoption of smFRET experiments by an ever-increasing number of groups has generated significant progress in sample preparation, measurement procedures, data analysis, alg … eLife is looking for early-career researchers who are interested in reviewing manuscripts in Structural Biology and Molecular Biophysics. Structural Biology and Molecular Biophysics. Structural Biology and Molecular Biophysics eLife publishes research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. DOI: 10.7554/eLife.10027 16 of 23 Research article Biophysics and structural biology | Cell biology Funder Grant reference Author New York State Foundation NYSBC grant Kaushik Dutta, David for Science, Technology and Cowburn Innovation (NYSTAR) U.S. Department of 900 MHz NMR David Cowburn Defense (DOD) purchase National Institute of General R01 . These macrocyclization reactions use the substrates amino terminus instead of water to deacylate, so a peptide bond is formed. DOI: 10.7554/eLife.21884 2 of 23 Research article Biochemistry Biophysics and Structural Biology A B C FEN1 cleavage reaction DNA-induced protein ordering Models for Upstream dsDNA substrate binding Single flap Double flap Unpaired (SF) (DF) Disorder 3'flap Equilibration 3'flap pocket Upstream DNA Template primer 3'flap T Cleavage . The nuclear RNA exosome complex mediates the processing of structured RNAs and the decay of aberrant non-coding RNAs, an important function particularly in human cells. +44 (0)1223 855373. 110 articles Last updated May 5, 2022. The senior editorial team is comprised of internationally-renowned, active researchers from Europe, North America . 7. View Record in Scopus Google Scholar. A. Amunts, et al. Structural Biology and Molecular Biophysics articles that have been evaluated by eLife. doi: . Research Interests. The new technique, called MicroED (micro electron diffraction), has the potential to accelerate structural biologists' efforts and to expand the repertoire of proteins whose high-resolution structures can be solved. eLife is an open-access journal that offers a platform for extending the reach and influence of new discoveries and to showcase new approaches to the presentation, use, and assessment of research. Emily Packer, Media Relations Manager. Structural Biology and Molecular Biophysics; Rate-limiting transport of positively charged arginine residues through the Sec-machinery is integral to the mechanism of protein secretion. Several techniques may be used to determine such structures. Most mechanistic studies to date have focused on the yeast system. Structural biology aims to deduce how such complexes function by determining the 3D arrangement of their atoms. Evolution has repeatedly recruited the Cys-protease asparaginyl endopeptidase (AEP) to perform their head-to-tail ligation. This represents the future of structural biology. This approach, known as electron crystallography, had previously been limited to studies . While 4D STEM is an incredibly powerful technique for structural characterization, it has been hampered by the fact that modern 4D STEM detectors are orders of magnitude slower than conventional analog STEM detectors. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware . Structural Biology and Molecular Biophysics. [PMC free article] [Google Scholar] 49. number of submissions have already been received and the first to be accepted reports an advance in a technique used in structural biology (Scheres, 2014). . eLife is a non-profit organisation inspired by research funders and led by scientists. Laboratory of Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University, Beijing, China. e.packer@elifesciences.org. Structural Biology and Molecular Biophysics articles that have been evaluated by eLife. 2016 Dec 23;5. pii: e19706. Elife. Mitochondrial antiviral signaling (MAVS) protein forms prion-like aggregates mediated by the N-terminal caspase activation and recruitment domain (CARD) and activates antiviral signaling cascades. While 4D STEM is an incredibly powerful technique for structural characterization, it has been hampered by the fact that modern 4D STEM detectors are orders of magnitude slower than conventional analog STEM detectors. In May, eLife published an open call for early-career researchers who were interested in reviewing manuscripts in Structural Biology and Molecular Biophysics. . The laboratory of Structural Cell Biology aims to understand the molecular mechanisms governing specialized cell shapes, such as those of neurons, activated immune cells or platelets and certain cancer cells. . eLife welcomes the submission of Research Articles, Short Reports, Tools and Resources articles, Research Advances, Scientific Correspondence and Review Articles in the subject areas below. . Author information: (1)Structural and Computational Biology Unit, European Molecular . Illustration by Davide Bonazzi Latest articles Structural Biology and Molecular Biophysics eLife is a non-profit organisation inspired by research funders and led by scientists. Structural snapshots of Xer recombination reveal activation by synaptic complex remodeling and DNA bending. The laboratory of Structural Cell Biology aims to understand the molecular mechanisms governing specialized cell shapes, such as those of neurons, activated immune cells or platelets and certain cancer cells. eLife e.packer@elifesciences.org 01223 855373. Elife, 2018. Using Gonen's new technique, scientists can use electrons from an electron microscope to determine the structure of protein microcrystals. This list contains. . We invite postdocs and independent investigators who have been running their own group for less than five years to apply to join our pool of early-career reviewers and learn more about the process of peer review. eLife is a non-profit organisation inspired by research funders and led by scientists. 6 Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom. Stem Cells and Regenerative Medicine; Structural Biology and Molecular Biophysics Join the conversation about this journal . eLife is a non-profit organisation inspired by research funders and led by scientists. Workshop outcomes: core problems and symptoms of problems. Lindahl, E. & Scheres, S. H. eLife 7, e36861 (2018). Over the past several years, Direct Electron has been . [A Brilot and N Grigorieff from eLife, 'Structural Biology: . eLife has introduced a new type of article-the Research Advance-that allows the authors of an eLife paper to publish results that build on their original research paper. The senior editorial team is today announced for eLife, the new top-tier, open-access research journal to be launched next year with the support of the Howard Hughes Medical Institute, the Max Planck Society and the Wellcome Trust. view more . Bebel A(1), Karaca E(1), Kumar B(1), Stark WM(2), Barabas O(1). Published in eLife, the study, titled . Article Google . Structure of the yeast mitochondrial large ribosomal subunit. eLife open-access scientific journal publishes outstanding research in the life sciences and biomedicine, from the most fundamental and theoretical work, through to translational, applied, and clinical research. Past several years, Direct Electron has been the latest research | eLife < /a > eLife ) and. 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